HLA - Human Leukocyte Antigen   Print Screen
* FluoroPharma

The human leukocyte antigen system (HLA) is a group of genes residing on chromosome 6 and encoding cell-surface antigen-presenting proteins and many other genes. Aside from the genes encoding the six major antigens, there are a large number of other genes, many involved in immune function located on the HLA complex.

Diversity of HLA in human population is one aspect of disease defense and, as a result, the chance of two unrelated individuals having identical HLA molecules on all loci is very low, except for non-identical siblings, which have a 25 percent chance of being HLA-identical.


Because of the seminal role played by HLA in human immunity and disease response, the HLA gene cluster is the most extensively studied set of genes in the human genome. The database grows daily but, at present, most genes of the HLA gene cluster have been resequenced among at least 20,000 individuals worldwide.

No other set of genes of the human genome has been re-sequenced to even one-tenth the level seen for HLA. As such, the HLA gene cluster can be thought of as the advanced guard, by several decades, of the level of genetic understanding that will be known elsewhere in the human genome.


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